I have today, as most days, heard from someone about a potential job opportunity in another dept. I applied and hope to hear back but most of these do not seem to pan out for me.

The job would be a step up in my field and pays significantly more money.
I have two issues/problems.

1. I need advice on how to advance myself, almost mid-career, when there is no direct career path in my field. I'm just making it up as I go along : ) Most of the time I get the interview, but no job offer.

2. Seeing as how I've mentioned that I would like to start a family soon, this may not be a good time to change jobs. Do managers take offense if you are new to a position and then announce your pregnancy? I think this is discrimination, but I know it happens.